(SportsNetwork.com) - Right-hander Clay Buchholz and the rest of the Boston Red Sox will try again to discover 2013 magic on Wednesday night when they host the Toronto Blue Jays in the second game of a three-game series at Fenway Park.

Boston dropped a 7-4 decision in Tuesday's opener for its fifth straight loss. It hasn't lost six consecutive games since the end of 2012, when it closed the season with eight straight defeats.

Buchholz was 12-1 in the turnaround 2013 season that yielded a World Series championship.

He's lost three of five decisions thus far in 2014 while posting an ugly 6.17 earned run average.

In his last start, on Thursday at Minnesota, Buchholz gave up three runs in six innings in a game the Red Sox ultimately lost, 4-3, in 10 innings.

He downed Toronto, 7-6, in April and is 10-5 in 18 career starts against the Blue Jays, though just two of those wins have come over seven starts in the series at Fenway Park.

For the Blue Jays, righty Drew Hutchinson returns after his best outing of the young season.

Hutchinson went the distance for his first shutout on Friday, defeating Texas, 2-0, while surrendering just three hits.

He's faced the Red Sox once, in Toronto, and won a 5-1 decision after pitching seven innings in June 2012.

On Tuesday, Edwin Encarnacion hit two of Toronto's four home runs, accounting for four RBI, as the Blue Jays took down Boston in the opener.

Melky Cabrera ended up 4-for-5 with a solo homer, two runs batted in and three scored for the Jays. Erik Kratz also went deep for the visitors.

J.A. Happ (3-1) allowed four runs on seven hits while fanning six and walking two over five-plus innings. Casey Janssen worked out of a jam in the ninth for his fourth save.

Jonny Gomes finished 3-for-4 with a two-run homer for the Red Sox. Dustin Pedroia and Jackie Bradley each drove in a run, too.

Felix Doubront (2-4) was tagged in the setback for five hits and as many runs while not surviving the fifth inning.

Boston took two of three from the Jays earlier in the year.