| Player | Position | Height | Weight | Age | Nationality |
| Hector Ambriz | P | 6'2 | 235 | 26 | United States |
| Michael Brantley | CF | 6'2 | 200 | 24 | United States |
| Asdrubal Cabrera | SS | 6'0 | 180 | 26 | Venezuela |
| Luke Carlin | C | 5'10 | 195 | 30 | United States |
| Fausto Carmona | P | 6'4 | 230 | 28 | Dominican Republic |
| Carlos Carrasco | P | 6'3 | 212 | 24 | Venezuela |
| Ezequiel Carrera | CF | 5'10 | 185 | 24 | Venezuela |
| Lonnie Chisenhall | 3B | 6'2 | 190 | 23 | United States |
| Shin-Soo Choo | RF | 5'11 | 205 | 29 | South Korea |
| Trevor Crowe | CF | 5'10 | 190 | 28 | United States |
| Jason Donald | SS | 6'1 | 190 | 27 | United States |
| Shelley Duncan | LF | 6'5 | 225 | 32 | United States |
| Kosuke Fukudome | RF | 6'0 | 200 | 34 | Japan |
| Jared Goedert | 2B | 6'1 | 205 | 26 | United States |
| Jeanmar Gomez | P | 6'3 | 170 | 23 | Venezuela |
| Travis Hafner | DH | 6'3 | 240 | 34 | United States |
| Nick Hagadone | P | 6'5 | 230 | 26 | United States |
| Jack Hannahan | 3B | 6'2 | 210 | 31 | United States |
| Frank Herrmann | P | 6'4 | 220 | 27 | United States |
| David Huff | P | 6'2 | 215 | 27 | United States |
| Chad Huffman | RF | 6'1 | 217 | 25 | United States |
| Ubaldo Jimenez | P | 6'4 | 210 | 28 | Dominican Republic |
| Nick Johnson | DH | 6'3 | 235 | 32 | United States |
| Jason Kipnis | 2B | 5'11 | 185 | 24 | United States |
| Corey Kluber | P | 6'4 | 215 | 25 | United States |
| Matt LaPorta | 1B | 6'2 | 215 | 27 | United States |
| Derek Lowe | P | 6'6 | 230 | 38 | United States |
| Lou Marson | C | 6'1 | 200 | 25 | United States |
| Justin Masterson | P | 6'6 | 250 | 26 | Jamaica |
| Doug Mathis | P | 6'3 | 220 | 27 | United States |
| Zach McAllister | P | 6'6 | 240 | 24 | United States |
| Matt Pagnozzi | C | 6'2 | 205 | 29 | United States |
| Chris Perez | P | 6'4 | 230 | 26 | United States |
| Rafael Perez | P | 6'3 | 195 | 29 | Dominican Republic |
| Vinnie Pestano | P | 6'0 | 200 | 26 | United States |
| Cord Phelps | 2B | 6'2 | 200 | 25 | United States |
| Paul Phillips | C | 5'11 | 200 | 33 | United States |
| Felix Pie | LF | 6'2 | 185 | 27 | Dominican Republic |
| Anthony Reyes | P | 6'2 | 230 | 29 | United States |
| Hector Rondon | P | 6'3 | 180 | 23 | Venezuela |
| Carlos Santana | C | 5'11 | 190 | 25 | Dominican Republic |
| Tony Sipp | P | 6'0 | 190 | 28 | United States |
| Grady Sizemore | CF | 6'2 | 200 | 29 | United States |
| Joe Smith | P | 6'2 | 205 | 27 | United States |
| Mitch Talbot | P | 6'2 | 200 | 28 | United States |
| Josh Tomlin | P | 6'1 | 190 | 27 | United States |
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