Sunday May 20, 2012
| Team | Player | Details |
| Oakland | Jim Miller | Called Up from Minors |
| LA Angels | Cory Aldridge | Signed to a Minor League Contract |
| San Diego | Orlando Hudson | Cleared Waivers and Became a Free Agent |
| NY Mets | Chris Schwinden | Called Up from Minors |
| Colorado | Rex Brothers | Sent to Minors |
| Houston | Jordan Lyles | Sent to Minors |
| Oakland | Brandon McCarthy | Placed on 15-Day DL (Strained right shoulder) |
| San Diego | Cory Luebke | Transferred to 60-Day DL (Left elbow soreness) |
| Colorado | Adam Ottavino | Called Up from Minors |
| Miami | Chris Coghlan | Called Up from Minors |
| Milwaukee | Carlos Gomez | Removed From 15-Day DL (Left hamstring strain) |
| Chi. Cubs | Brian Esposito | Signed to a Minor League Contract |
| Miami | Emilio Bonifacio | Placed on 15-Day DL (Left thumb sprain) |
| San Diego | Matt Palmer | Purchased From Minors |
| Pittsburgh | Drew Sutton | Traded From Atlanta (for cash considerations) |
| Pittsburgh | Jeff Locke | Called Up from Minors |
| St. Louis | Matt Adams | Purchased From Minors |
| San Diego | Nick Vincent | Sent to Minors |
| Pittsburgh | Jason Grilli | Placed on Bereavement/Family Medical Emergency List |
| Boston | Mauro Gomez | Sent to Minors |
| Boston | Che-Hsuan Lin | Called Up from Minors |
| St. Louis | Lance Berkman | Placed on 15-Day DL (Torn meniscus, right knee) |
| Miami | Donovan Solano | Purchased From Minors |
| NY Mets | Miguel Batista | Placed on 15-Day DL (Lower back stiffness) |
Monday May 21, 2012
| Team | Player | Details |
| Houston | Armando Galarraga | Signed to a Minor League Contract |
| Tampa Bay | Jeff Keppinger | Placed on 15-Day DL (Broken right big toe) |
| Texas | Neftali Feliz | Placed on 15-Day DL (Right elbow inflammation) |
| St. Louis | Lou Montanez | Signed to a Minor League Contract |
| Houston | Enerio Del Rosario | Called Up from Minors |
| Atlanta | Lance Zawadzki | Signed to a Minor League Contract |
| Chi. Cubs | Carlos Marmol | Sent to Minors For Rehabilitation |
| Arizona | Josh Bell | Called Up from Minors |
| Pittsburgh | Jeff Karstens | Sent to Minors For Rehabilitation |
| Tampa Bay | Drew Sutton | Purchased From Minors |
| Colorado | Chris Nelson | Sent to Minors For Rehabilitation |
| LA Angels | Vernon Wells | Placed on 15-Day DL (Torn ligament, right thumb) |
| Arizona | Daniel Hudson | Sent to Minors For Rehabilitation |
| NY Mets | Vinny Rottino | Called Up from Minors |
| Tampa Bay | John Gaub | Designated for Assignment |
| Toronto | Brett Lawrie | Reinstated From League Suspension |
| Oakland | Coco Crisp | Removed From 15-Day DL (Inner ear infection) |
| Seattle | Miguel Olivo | Sent to Minors For Rehabilitation |
| Texas | Yoshinori Tateyama | Called Up from Minors |
| Milwaukee | Vinnie Chulk | Outrighted to Minors |
| NY Mets | Chris Schwinden | Sent to Minors |
| Chi. Cubs | Steve Clevenger | Sent to Minors For Rehabilitation |
| Arizona | Cody Ransom | Designated for Assignment |
| Oakland | Eric Sogard | Sent to Minors |
| Baltimore | Josh Barfield | Signed to a Minor League Contract |
Tuesday May 22, 2012
| Team | Player | Details |
| Chi. White Sox | Brent Morel | Placed on 15-Day DL (Lumbar back strain) |
| Boston | Daisuke Matsuzaka | Transferred to 60-Day DL (Recovery from right elbow surgery) |
| LA Angels | Kole Calhoun | Purchased From Minors |
| Oakland | Graham Godfrey | Called Up from Minors |
| Kansas City | Will Smith | Purchased From Minors |
| Washington | Ryan Mattheus | Placed on 15-Day DL (Plantar fasciitis, left foot) |
| Minnesota | Cole De Vries | Purchased From Minors |
| St. Louis | Aaron Bates | Signed to a Minor League Contract |
| NY Mets | Josh Thole | Transferred to 15-Day DL (Concussion) |
| LA Angels | Michael Kohn | Transferred to 60-Day DL (Right elbow surgery - out for season) |
| Philadelphia | Erik Kratz | Called Up from Minors |
| Arizona | Patrick Corbin | Sent to Minors |
| Detroit | Danny Worth | Called Up from Minors |
| Kansas City | Blake Wood | Transferred to 60-Day DL (Right elbow surgery - out for season) |
| Arizona | Konrad Schmidt | Called Up from Minors |
| LA Angels | Bobby Cassevah | Called Up from Minors |
| Chi. Cubs | Travis Wood | Called Up from Minors |
| Pittsburgh | Jeff Locke | Sent to Minors |
| Oakland | Pedro Figueroa | Sent to Minors |
| Chi. Cubs | Welington Castillo | Placed on 15-Day DL (Sprained right knee) |
| Boston | Scott Podsednik | Purchased From Minors |
| Boston | Ryan Sweeney | Placed on 7-Day DL (Concussion) |
| Detroit | Ryan Raburn | Placed on Bereavement/Family Medical Emergency List |
| Washington | Chien-Ming Wang | Removed From 15-Day DL (Strained left hamstring) |
| Philadelphia | Jimmy Rollins | Placed on Paternity Leave List |
| Kansas City | Chris Getz | Placed on 15-Day DL (Left ribcage contusion) |
| Chi. White Sox | Orlando Hudson | Signed as Free Agent ( 2012)(one-year contract) |
| LA Angels | Ryan Langerhans | Placed on 15-Day DL (Separated right shoulder) |
| Boston | Kevin Youkilis | Removed From 15-Day DL (Lower left back tightness) |
| Minnesota | Jason Marquis | Designated for Assignment |
| Boston | Cody Ross | Placed on 15-Day DL (Fractured left foot) |
Wednesday May 23, 2012
| Team | Player | Details |
| Pittsburgh | Jason Grilli | Reinstated from Bereavement/Family Medical Emergency List |
| Philadelphia | Erik Kratz | Sent to Minors |
| St. Louis | Matt Carpenter | Placed on 15-Day DL (Strained right oblique) |
| Colorado | DJ LeMahieu | Called Up from Minors |
| Colorado | Jonathan Herrera | Placed on 15-Day DL (Strained right hamstring) |
| San Francisco | Charlie Culberson | Sent to Minors |
| St. Louis | Steven Hill | Purchased From Minors |
| Milwaukee | Edwin Maysonet | Sent to Minors |
| Detroit | Quintin Berry | Purchased From Minors |
| Detroit | Collin Balester | Designated for Assignment |
| Milwaukee | Alex Gonzalez | Transferred to 60-Day DL (Right knee injury) |
| Pittsburgh | Jeff Locke | Sent to Minors |
| LA Dodgers | Jerry Hairston Jr. | Sent to Minors For Rehabilitation |
| Baltimore | Brian Roberts | Sent to Minors For Rehabilitation |
| Milwaukee | Cody Ransom | Acquired Off Waivers From Arizona |
Thursday May 24, 2012
| Team | Player | Details |
| Seattle | Miguel Olivo | Removed From 15-Day DL (Strained right groin) |
| Philadelphia | Jimmy Rollins | Reinstated from Paternity Leave List |
| Detroit | Luke Putkonen | Sent to Minors |
| Texas | John Gaub | Sent to Minors |
| Miami | Kevin Mattison | Called Up from Minors |
| Miami | Austin Kearns | Placed on 15-Day DL (Strained right hamstring) |
| LA Angels | Andrew Romine | Called Up from Minors |
| Milwaukee | Marco Estrada | Placed on 15-Day DL (Right quadriceps strain) |
| Miami | Mike Dunn | Sent to Minors |
| LA Angels | David Pauley | Designated for Assignment |
| San Francisco | Ryan Theriot | Removed From 15-Day DL (Right elbow inflammation) |
| Baltimore | J.C. Romero | Signed to a Minor League Contract |
| Seattle | Casper Wells | Sent to Minors |
| Kansas City | Yuniesky Betancourt | Sent to Minors For Rehabilitation |
| Toronto | Paul Phillips | Traded From Milwaukee (for cash considerations) |
| Cincinnati | Joey Gathright | Signed to a Minor League Contract |
| Detroit | Austin Jackson | Placed on 15-Day DL (Abdominal strain) |
Friday May 25, 2012
| Team | Player | Details |
| Cleveland | Juan Diaz | Called Up from Minors |
| Miami | Dan Jennings | Called Up from Minors |
| Baltimore | Stu Pomeranz | Called Up from Minors |
| LA Dodgers | Jerry Hairston Jr. | Removed From 15-Day DL (Left hamstring strain) |
| Colorado | Ramon Hernandez | Placed on 15-Day DL (Strained muscle, left hand) |
| Pittsburgh | Matt Hague | Called Up from Minors |
| Chi. White Sox | Jose Quintana | Called Up from Minors |
| Toronto | Evan Crawford | Sent to Minors |
| NY Mets | Robert Carson | Sent to Minors |
| Boston | Darnell McDonald | Sent to Minors For Rehabilitation |
| Colorado | Hector Gomez | Transferred to 60-Day DL (Strained right groin) |
| Milwaukee | Mike McClendon | Called Up from Minors |
| NY Yankees | John Maine | Signed to a Minor League Contract |
| Detroit | Ryan Raburn | Reinstated from Bereavement/Family Medical Emergency List |
| Pittsburgh | Nate McLouth | Designated for Assignment |
| LA Angels | David Pauley | Outrighted to Minors |
| Chi. White Sox | John Danks | Placed on 15-Day DL (Sore left shoulder) |
| Toronto | Ryota Igarashi | Purchased From Minors |
| Toronto | Ben Francisco | Placed on 15-Day DL (Strained left hamstring) |
| NY Mets | Jack Egbert | Purchased From Minors |
| Toronto | Dustin McGowan | Transferred to 60-Day DL (Plantar fasciitis, right foot) |
| Baltimore | Ronny Paulino | Called Up from Minors |
| Oakland | Brandon Inge | Sent to Minors For Rehabilitation |
| Detroit | Luis Marte | Called Up from Minors |
| LA Dodgers | Justin Sellers | Placed on 15-Day DL (Bulging disc in lower back) |
| Cleveland | Zach McAllister | Sent to Minors |
| Baltimore | Luis Exposito | Sent to Minors |
| Colorado | Wil Nieves | Purchased From Minors |
| Baltimore | Bill Hall | Designated for Assignment |
| Toronto | David Cooper | Called Up from Minors |
| NY Mets | D.J. Carrasco | Released |
| Detroit | Austin Jackson | Placed on 15-Day DL (Abdominal strain) |
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