| Date | WK | Opponent | Result | W-L | HI Passing | HI Rushing | HI Receiving |
| Aug 12, 2011 | Ex | San Francisco | Won 24-3 | -- | Daniel - 129 | Bell - 52 | Roby - 42 |
| Aug 20, 2011 | Ex | at Houston | Lost 27-14 | -- | Daniel - 127 | Thomas - 33 | Morgan - 56 |
| Aug 28, 2011 | Ex | at Oakland | Won 40-20 | -- | Daniel - 191 | Bell - 50 | Bell - 92 |
| Sep 1, 2011 | Ex | Tennessee | Lost 32-9 | -- | Canfield - 249 | Bell - 80 | Bell - 44 |
| Sep 8, 2011 | 1 | at Green Bay | Lost 42-34 | 0-1 | Brees - 419 | Ingram - 40 | Henderson - 100 |
| Sep 18, 2011 | 2 | Chicago | Won 30-13 | 1-1 | Brees - 270 | Ingram - 51 | Henderson - 103 |
| Sep 25, 2011 | 3 | Houston | Won 40-33 | 2-1 | Brees - 370 | Ingram - 38 | Graham - 100 |
| Oct 2, 2011 | 4 | at Jacksonville | Won 23-10 | 3-1 | Brees - 351 | Sproles - 75 | Graham - 132 |
| Oct 9, 2011 | 5 | at Carolina | Won 30-27 | 4-1 | Brees - 359 | Sproles - 51 | Graham - 129 |
| Oct 16, 2011 | 6 | at Tampa Bay | Lost 26-20 | 4-2 | Brees - 383 | Ingram - 22 | Graham - 124 |
| Oct 23, 2011 | 7 | Indianapolis | Won 62-7 | 5-2 | Brees - 325 | Ingram - 91 | Colston - 98 |
| Oct 30, 2011 | 8 | at St. Louis | Lost 31-21 | 5-3 | Brees - 269 | Thomas - 23 | Moore - 74 |
| Nov 6, 2011 | 9 | Tampa Bay | Won 27-16 | 6-3 | Brees - 258 | Ivory - 67 | Graham - 78 |
| Nov 13, 2011 | 10 | at Atlanta | Won 26-23 | 7-3 | Brees - 322 | Thomas - 29 | Colston - 113 |
| Nov 28, 2011 | 12 | NY Giants | Won 49-24 | 8-3 | Brees - 363 | Ingram - 80 | Graham - 84 |
| Dec 4, 2011 | 13 | Detroit | Won 31-17 | 9-3 | Brees - 342 | Ingram - 54 | Meachem - 119 |
| Dec 11, 2011 | 14 | at Tennessee | Won 22-17 | 10-3 | Brees - 337 | Ivory - 53 | Colston - 105 |
| Dec 18, 2011 | 15 | at Minnesota | Won 42-20 | 11-3 | Brees - 412 | Ivory - 74 | Moore - 91 |
| Dec 26, 2011 | 16 | Atlanta | Won 45-16 | 12-3 | Brees - 307 | Sproles - 67 | Colston - 81 |
| Jan 1, 2012 | 17 | Carolina | Won 45-17 | 13-3 | Brees - 389 | Ivory - 127 | Colston - 145 |
| Jan 7, 2012 | 18 | Detroit | Won 45-28 | 14-3 | Brees - 466 | Thomas - 66 | Colston - 120 |
| Jan 14, 2012 | 19 | at San Francisco | Lost 36-32 | 14-4 | Brees - 462 | Ivory - 23 | Colston - 136 |
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