NFL San Francisco 49ers

- Feb 5, 2012: Curtis Holcomb - Taken off IR (ruptured Achilles tendon)
- Feb 5, 2012: Nate Byham - Taken off IR (torn ACL)
- Feb 5, 2012: Josh Morgan - Taken off IR (broken leg)
- Feb 5, 2012: Will Tukuafu - Taken off IR (undisclosed)
- Feb 5, 2012: Dontavia Bogan - Taken off IR (torn right ACL)
- Jan 30, 2012: Kenny Wiggins - signed
- Jan 30, 2012: Garrett Chisolm - signed
- Jan 29, 2012: John Matthews - signed
- Jan 26, 2012: John Matthews - signed
- Jan 23, 2012: Kyle Nelson - signed
- Jan 23, 2012: Derek Hall - signed
- Jan 23, 2012: Chase Beeler - signed
- Jan 23, 2012: Cory Nelms - signed
- Jan 23, 2012: Michael Wilhoite - signed
- Jan 23, 2012: Mark LeGree - signed
- Jan 23, 2012: Konrad Reuland - signed
- Jan 9, 2012: Kyle Nelson - signed
- Jan 4, 2012: Ricky Elmore - practice squad addition
- Jan 4, 2012: Bruce Davis - practice squad deletion
- Jan 2, 2012: Bruce Davis - practice squad addition
- Dec 30, 2011: Joe Hastings - Activated from the Practice Squad
- Dec 26, 2011: Braylon Edwards - cut
- Dec 13, 2011: Ian Johnson - practice squad deletion
- Dec 13, 2011: Michael Wilhoite - practice squad addition
- Dec 7, 2011: Alex Boone - re-signed (Four-year extension (through 2015))
- Nov 28, 2011: John Matthews - practice squad addition
- Nov 28, 2011: Mark LeGree - practice squad deletion
- Nov 22, 2011: Alex Boone - re-signed (Four-year extension (through 2014))
- Nov 14, 2011: John Matthews - practice squad deletion
- Nov 14, 2011: Mark LeGree - practice squad addition
- Oct 17, 2011: Kerry Taylor - practice squad deletion
- Oct 17, 2011: Chase Beeler - practice squad addition
- Oct 11, 2011: Chase Beeler - practice squad deletion
- Oct 11, 2011: Josh Morgan - Placed on IR (broken leg)
- Oct 11, 2011: Kerry Taylor - practice squad addition
- Oct 11, 2011: Brett Swain - signed
- Oct 3, 2011: John Matthews - practice squad addition
- Oct 3, 2011: Colin Jones - Activated from the Practice Squad
- Oct 3, 2011: Will Tukuafu - Placed on IR (undisclosed)
- Sep 13, 2011: Colin Jones - practice squad addition
- Sep 12, 2011: Colin Jones - cut
- Sep 12, 2011: Justin Peelle - signed/unrestricted free agent (One-year contract)
- Sep 11, 2011: Xavier Omon - practice squad deletion
- Sep 11, 2011: Ian Johnson - practice squad addition
- Sep 5, 2011: Tavares Gooden - signed (One-year contract)
- Sep 5, 2011: Antwan Applewhite - cut
- Sep 4, 2011: Tavares Gooden - signed
- Sep 3, 2011: Konrad Reuland - practice squad addition
- Sep 3, 2011: Keaton Kristick - cut
- Sep 3, 2011: Scott Tolzien - acquired from waivers
- Sep 3, 2011: Chase Beeler - practice squad addition
- Sep 3, 2011: Cory Nelms - practice squad addition
- Sep 3, 2011: Xavier Omon - practice squad addition
- Sep 3, 2011: Joe Hastings - practice squad addition
- Sep 3, 2011: Derek Hall - practice squad addition
- Sep 3, 2011: Monte Simmons - practice squad addition
- Sep 2, 2011: Josh McCown - cut
- Sep 2, 2011: Phillip Davis - cut
- Sep 2, 2011: Phillip Adams - cut
- Sep 2, 2011: Tony Wragge - cut
- Sep 2, 2011: Nate Byham - Placed on IR (torn ACL)
- Sep 2, 2011: Kenny Wiggins - cut
- Sep 2, 2011: Chris Maragos - cut
- Sep 2, 2011: McLeod Bethel-Thompson - cut
- Sep 2, 2011: Brian Bulcke - cut
- Sep 2, 2011: Jack Corcoran - cut
- Sep 2, 2011: Alex Joseph - cut
- Sep 2, 2011: Ronald Johnson - cut
- Sep 2, 2011: Monte Simmons - cut
- Sep 2, 2011: Cory Nelms - cut
- Sep 2, 2011: Anthony West - cut
- Sep 2, 2011: Dominique Zeigler - cut
- Sep 2, 2011: Derek Hall - cut
- Sep 2, 2011: Joe Hastings - cut
- Sep 2, 2011: Xavier Omon - cut
- Sep 2, 2011: Lance Long - cut
- Sep 2, 2011: Chase Beeler - cut
- Sep 2, 2011: Curtis Taylor - cut
- Sep 2, 2011: Chris Hogan - cut
- Sep 2, 2011: Nate Lawrie - cut
- Sep 2, 2011: Konrad Reuland - cut
- Sep 2, 2011: Kenny Rowe - cut
- Sep 2, 2011: Sealver Siliga - cut
- Aug 30, 2011: Frank Gore - re-signed (Three-year extension (through 2014))
- Aug 29, 2011: Nick Howell - cut
- Aug 29, 2011: Sam Paulescu - cut
- Aug 29, 2011: Donovan Edwards - cut
- Aug 29, 2011: Kevin Jurovich - cut
- Aug 29, 2011: Seth Smith - cut
- Aug 29, 2011: Tyler Beiler - cut
- Aug 29, 2011: Scott McKillop - cut
- Aug 23, 2011: Colin Cloherty - cut
- Aug 21, 2011: Fabrizio Scaccia - cut
- Aug 21, 2011: Sam Paulescu - signed
- Aug 21, 2011: Jeremiah Masoli - cut
- Aug 16, 2011: Josh McCown - signed/unrestricted free agent (One-year contract)
- Aug 14, 2011: Thaddeus Gibson - cut
- Aug 13, 2011: Nate Lawrie - signed (One-year contract)
- Aug 10, 2011: Scott McKillop - cut
- Aug 9, 2011: Chris Blohm - cut
- Aug 7, 2011: Chris Blohm - signed (Three-year contract)
- Aug 7, 2011: Dashon Goldson - re-signed/unrestricted free agent (One-year contract)
- Aug 6, 2011: Curtis Holcomb - Placed on IR (ruptured Achilles tendon)
- Aug 6, 2011: Dontavia Bogan - Placed on IR (torn right ACL)
- Aug 3, 2011: Braylon Edwards - signed/unrestricted free agent (One-year contract)
- Aug 3, 2011: Donte Whitner - signed/unrestricted free agent (Three-year contract)
- Aug 2, 2011: Blake Costanzo - signed/unrestricted free agent (One-year contract)
- Aug 2, 2011: Carlos Rogers - signed/unrestricted free agent (One-year contract)
- Aug 2, 2011: Jonathan Goodwin - signed/unrestricted free agent (Three-year contract)
- Aug 2, 2011: Madieu Williams - signed (One-year contract)
- Aug 1, 2011: Carlos Rogers - signed/unrestricted free agent (One-year contract)
- Aug 1, 2011: Phillip Davis - signed
- Jul 31, 2011: Madieu Williams - signed
- Jul 30, 2011: Larry Grant - signed/unrestricted free agent (One-year contract)
- Jul 30, 2011: Antwan Applewhite - signed/unrestricted free agent (One-year contract)
- Jul 29, 2011: C.J. Spillman - re-signed/exclusive rights free agent
- Jul 29, 2011: Jack Corcoran - signed/unrestricted free agent (Three-year contract)
- Jul 29, 2011: Nate Clements - cut
- Jul 29, 2011: David Akers - signed/unrestricted free agent (Three-year contract)
- Jul 28, 2011: Ray McDonald - re-signed/unrestricted free agent (Five-year contract)
- Jul 28, 2011: Alex Smith - re-signed/unrestricted free agent (One-year contract)
- Jul 28, 2011: Joe Nedney - cut
- Jul 28, 2011: Tony Wragge - re-signed/unrestricted free agent (One-year contract)
- Jul 28, 2011: Eric Heitmann - cut
- Jul 27, 2011: McLeod Bethel-Thompson - signed
- Jul 27, 2011: Monte Simmons - signed
- Jul 27, 2011: Mike Person - signed/draft choice (Four-year contract)
- Jul 27, 2011: David Carr - cut
- Jul 27, 2011: Ronald Johnson - signed/draft choice (Four-year contract)
- Jul 27, 2011: Curtis Holcomb - signed/draft choice (Four-year contract)
- Jul 27, 2011: Chris Culliver - signed/draft choice (Four-year contract)
- Jul 27, 2011: Aldon Smith - signed/draft choice (Four-year contract (fifth-year option))
- Jul 27, 2011: Colin Kaepernick - signed/draft choice (Four-year contract)
- Jul 27, 2011: Colin Jones - signed/draft choice (Four-year contract)
- Jul 27, 2011: Kendall Hunter - signed/draft choice (Four-year contract)
- Jul 26, 2011: Demarcus Dobbs - signed
- Jul 26, 2011: Tyler Beiler - signed
- Jul 26, 2011: Daniel Kilgore - signed/draft choice (Four-year contract)
- Jul 26, 2011: Seth Smith - signed
- Jul 26, 2011: Chase Beeler - signed
- Jul 26, 2011: Chris Hogan - signed
- Jul 26, 2011: Bruce Miller - signed/draft choice (Four-year contract)
- Jul 26, 2011: Joe Hastings - signed
- Jul 26, 2011: Cory Nelms - signed
- Jul 26, 2011: Brian Bulcke - signed
- Jul 26, 2011: Sealver Siliga - signed
- Jul 26, 2011: Anthony West - signed
- Jul 26, 2011: Kenny Wiggins - signed
- Jul 26, 2011: Jeremiah Masoli - signed
- Jul 26, 2011: Konrad Reuland - signed
- Jul 26, 2011: Ian Williams - signed
- Jul 26, 2011: Dontavia Bogan - signed
- Jul 26, 2011: Derek Hall - signed
- Jul 26, 2011: Donovan Edwards - signed
- Jul 26, 2011: Kenny Rowe - signed
- Jul 24, 2011: Dashon Goldson - declared free agent
- Jul 24, 2011: Barry Sims - declared free agent
- Jul 24, 2011: Ray McDonald - declared free agent
- Jul 24, 2011: Manny Lawson - declared free agent
- Jul 24, 2011: Takeo Spikes - declared free agent
- Jul 24, 2011: Aubrayo Franklin - declared free agent
- Jul 24, 2011: Demetric Evans - declared free agent
- Jul 24, 2011: Chris Patrick - declared free agent
- Jul 24, 2011: Tony Wragge - declared free agent
- Jul 24, 2011: Jeff Reed - declared free agent
- Jul 24, 2011: Travis LaBoy - declared free agent
- Jul 24, 2011: Troy Smith - declared free agent
- Jul 24, 2011: Brian Westbrook - declared free agent
- Jul 24, 2011: David Baas - declared free agent
- Jul 24, 2011: Alex Smith - declared free agent
- Jul 24, 2011: William James - declared free agent