McCaw is dealing with left knee soreness and Brissett is dealing with right knee soreness, according to the NBA’s official injury report.
McCaw, 24, averaged 4.6 points, 2.3 rebounds and 2.1 assists in 24.5 minutes per game this season.
Brissett, 22, has appeared in 19 games for the Raptors this season.
The Raptors will play their first game of the NBA’s restart following the season’s suspension in March due to the COVID-19 pandemic. The Lakers resumed their campaign against the Los Angeles Clippers on Thursday.