NFL Week 6 odds: Unbeaten Niners listed as underdogs


San Francisco 49ers tight end George Kittle, right, celebrates with Dante Pettis, center, and Ross Dwelley after scoring against the Cleveland Browns. (Tony Avelar/AP)

The San Francisco 49ers will be looking to extend their lead atop the NFC West standings on Sunday when they take on the division rival Los Angeles Rams as 3.5-point road underdogs on the Week 6 NFL odds at sportsbooks monitored by

San Francisco returned to action on Monday following an early-season bye in Week 4 and dominated in a 31-3 win over the visiting Cleveland Browns as five-point chalk, lifting their straight-up record to a perfect 4-0 going into Sunday afternoon’s matchup at Los Angeles Memorial Coliseum.

The 49ers outpaced Cleveland in virtually every statistical category, racking up 446 total yards while limiting the Browns to just 180 total yards and forcing four turnovers. One of just two NFL teams that remain undefeated entering Week 6, the Niners also sit among the league leaders in points per game at 31.8 and have yet to allow a rushing touchdown so far this season. San Francisco has made steady gains on the Super Bowl odds during its best start since 1990, and now sit just short of the favourites as a +1500 wager.

The Rams return home looking for answers after dropping a 30-29 decision in Seattle last week on Thursday Night Football, moving to 3-2 on the season. Los Angeles has surrendered 85 total points over its two-game slide, but has avoided posting three consecutive SU losses since the final three weeks of the 2016 NFL season.

In addition, the Rams have scored 39 or more points on three occasions during a 3-1 run against San Francisco, capped by a 48-13 rout as 10.5-point chalk at online sports betting sites in Week 17 of last season, but have failed to tally consecutive home wins over the 49ers since 2004.

Elsewhere on the NFL Week 6 odds, the Patriots will be poised to improve to a perfect 6-0 when they host the New York Giants on Thursday Night Football as 16.5-point betting chalk. The Seahawks will try to keep pace with the 49ers as they visit Cleveland as narrow 1.5-point favourites, while a battle of winless squads sees the Washington Redskins visiting the Miami Dolphins as 3.5-point chalk.

The Patriots have racked up 31.5 points per game during their 5-0 start, and ride a 10-game SU win streak that dates back to Week 6 of last season. The Giants took a step back after rookie quarterback Daniel Jones led them to consecutive wins in his debut as an NFL starter, falling 28-10 to Minnesota, but have covered in five straight meetings with the Patriots.

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