Muzzin was hurt in the first period after a collision with the Capitals’ Tom Wilson. He appeared in just over four minutes of ice time before the injury.
The 30-year-old has three goals and nine points in 13 games this season.
Muzzin wasn’t the only player to leave the game with an injury. The Capitals announced that forward Nick Dowd would not return with his own lower-body injury. And Evgeny Kuznetsov also left the game after a collision with Alexander Kerfott, but he was able to return shortly after.