James was initially listed as probable for Tuesday's game after he fell to the floor holding his right leg in the second quarter of Sunday's win against the Memphis Grizzlies. He still managed to play the rest of the game. Earlier on Tuesday, James was listed as questionable for the Lakers game versus the Spurs.
According to Lakers head coach Frank Vogel, James is questionable for Wednesday's game against the Oklahoma City Thunder.
The 36-year-old missed much of last season with a right ankle injury.
Three games into his 19th NBA season, the 17-time all-star is averaging 26 points, 6.3 rebounds and 5.3 assists for the 1-2 Lakers.