The teams open the best-of-seven series Saturday in Philadelphia before the 76ers host Game 2 next Monday (April 18).
The series then shifts to Toronto's Scotiabank Arena for Games 3 (April 20) and 4 (April 23).
It is the third playoff series between the teams. Philadelphia won in seven games in the second round in 2001, while the Raptors won a seven-gamer in the second round en route to the NBA title in 2019.
Broadcast details have not been announced.
Here is the full schedule (All times Eastern):
Game 1: Saturday, April 16, 6 p.m., at Philadelphia
Game 2: Monday, April 18, 7:30 p.m., at Philadelphia
Game 3: Wednesday, April 20, 8 p.m., at Toronto
Game 4: Saturday, April 23, 2 p.m., at Toronto
Game 5 (if necessary), Monday, April 25, Time TBD, at Philadelphia
Game 6 (if necessary), Thursday, April 28, Time TBD, at Toronto
Game 7 (if necessary), Saturday, April 30, Time TBD, at Philadelphia
You can find the full schedules for the other first-round series here.