Detroit will host the Bulls on Wednesday night without Cunningham, the No. 1 overall pick in the NBA draft. Cunningham hurt his ankle early in training camp and did not play in the preseason.
Detroit is counting on the 6-foot-8 guard to help restore success.
The Pistons have earned a spot in the playoffs just twice since 2009, when they ended an eight-year playoff run that included their third NBA championship, two Eastern Conference titles and six trips to the conference finals.