Lowry had missed the past four games with a thumb injury.
Lowry was injured last week in a win over the Milwaukee Bucks. In 25 games this season, the 34-year-old is averaging 17.7 points a game, 5.4 rebounds and 6.4 assists.
Forward OG Anunoby, who was rested on the second game of a back-to-back last week, will also be available Wednesday.
On the Heat side of the ball, star guard Goran Dragic -- who had been out since Feb. 5 with an ankle injury -- will return to the lineup Wednesday.