CJ McCollum scored 22 points and former Toronto Raptors centre Jonas Valanciunas and Brandon Ingram added 19 apiece for the Pelicans.
The 28-point margin of victory is the largest in franchise history by the Pelicans over the Lakers, surpassing their 139-117 win in 2018.
McCollum has six straight 20-point games. He is averaging 28 points in his seven games with the Pelicans since being acquired from Portland on Feb. 8. He had nine points in the third quarter when New Orleans went on a 26-7 run over four-plus minutes to put the game away.
Valanciunas also had 10 rebounds for his 37th double-double of the season, which is tied for third in the NBA.
Ingram, who played for the Lakers for three seasons, also had eight assists. He had six points during the last six minutes of the first half as the Pelicans went on a 17-4 run to grab a 51-37 lead with 35 seconds remaining. LeBron James banked in a 3-pointer on the ensuing possession to pull the Lakers within 51-40 at halftime.
James led the Lakers with 32 points and Russell Westbrook added 16. Los Angeles has dropped two straight and five of its last six to fall a season-worst six games under .500 at 27-33.
The Lakers committed 23 turnovers, including 16 in the first half. Los Angeles’ night could be summed up during the third quarter when DeAndre Jordan threw a cross-court pass that hit a fan in the first row of the seats along the baseline.
Fans at crypto.com Arena voiced their displeasure with boos for most of the second half.
Pelicans: New Orleans has won five straight road games, marking the fifth time that has happened since the team moved from Charlotte in 2002. The longest streak is eight in 2007-08.
Lakers: Dwight Howard finished with 11 rebounds. He reached 10,400 career defensive rebounds midway through the second quarter.
Pelicans: Host the Sacramento Kings on Wednesday.
Lakers: Host the Dallas Mavericks on Tuesday.