Two of the NFL's top running backs this season are facing uncertain futures after being forced to leave games early with injuries on Sunday.
Cleveland halfback Nick Chubb, who is fourth in the league in rushing entering the week, sustained a knee injury. Los Angeles Chargers back Austin Ekeler, who was eighth, was carted off with what seemed like a serious hamstring injury.
Chubb was injured in the first quarter when his right leg was rolled up on by a pair of opposing linemen engaged with each other. He limped to the locker room. Coach Kevin Stefanski said Chubb will have an MRI. He did not know the extent of the injury.
The Browns ran for 307 yards and three touchdowns despite losing Chubb.
Ekeler left a game against the Tampa Bay Buccaneers late in the first quarter after hurting his hamstring breaking a tackle in the flat. He had trouble getting into the cart on the sideline.
"The way he limped off the field it was pretty bad,'' said Chargers coach Anthony Lynn, who called Ekeler a special player.
Tampa Bay's win over the Chargers did not come without injury. Tight end O.J. Howard was lost to an Achilles tendon injury, while running backs LeSean McCoy (ankle) and Kenjon Barner (concussion) did not finish.
There were a couple of other injuries in the Browns' win over the Dallas Cowboys.
Browns receiver KhaDarel Hodge hurt his hamstring in pregame warmups and did not play. Defensive tackle Larry Ogunjobi left with an abdominal injury. The Cowboys had centre Joe Looney injure his right knee on the first offensive play of the game and not return. He was replaced by rookie Tyler Biadasz.
The Saints lost offensive tackle Ryan Ramczyk (concussion) and receiver-returner Deonte Harris (undisclosed) against Detroit. The Lions had cornerback Desmond Trufant aggravate a hamstring injury in his first game of the season. Defensive tackle Nick Williams left with a shoulder injury.
Houston Texans tight end Jordan Akins was knocked out of a game against Minnesota with a concussion. Vikings safety Harrison Smith was ejected for a leaping helmet-to-helmet hit on the play.
The Washington Redskins saw safety Greg Stroman injured his right leg on an ill-advised punt return. He left the game.
The Carolina Panthers lost cornerback Eli Apple to a hamstring injury in their win over the Arizona Cardinals.
The Jacksonville Jaguars lost more than a game in Cincinnati. Cornerback CJ Henderson (shoulder), linebacker Myles Jack (ankle), tight end Tyler Eifert (concussion) and cornerback D.J. Hayden (hamstring) all left the game. The Bengals had receiver A.J. Green leave with a wrist injury.
There were a couple of injuries in the late games.
Buffalo Bills cornerback Levi Wallace ?was ruled out after suffering a left ankle injury in the first half against Las Vegas. The Raiders had defensive back Lamarcus Joyner (rib) and defensive tackle Maliek Collins (shoulder) leave the game.
Indianapolis Colts lost linebacker Darius Leonard against Chicago with a groin injury.
