The Colts will be without a key offensive weapon Sunday.
Star tight end Tyler Warren is out for Indianapolis' divisional contest vs. Tennessee, the Colts announced prior to kickoff.
Warren had been questionable since Friday after sustaining a groin injury in practice.
The 24-year-old leads the Colts with two receiving touchdowns on the season, along with 213 receiving yards in five games.
The Colts (2-3) are looking to get back to .500 while the Titans are searching for their first win of the season.
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