The NFL is heading back overseas.
Week 4's Sunday action begins when the Indianapolis Colts and Washington Commanders meet in London at 9:30 a.m. ET — and that's just the start of a loaded Sunday slate, with five teams still undefeated and five others searching for win No. 1.
There are also plenty of intriguing quarterback matchups and divisional games on the schedule.
One of the biggest games comes in Buffalo, where Josh Allen and the Bills will put their perfect record on the line against a New England Patriots team looking for answers.
Here are some of the biggest storylines:
Can the Raiders stay perfect?
Remember when the Raiders won just three games last season?
Well, they have already matched that total.
Las Vegas has found different ways to win this season. Its defence has forced nine turnovers (plus-five differential) and recorded 10 sacks, all while not allowing a fourth-quarter point.
The defence came up big again last week, forcing four turnovers in the fourth quarter of a 35-27 comeback win over New Orleans.
Kirk Cousins has also provided stability at quarterback, throwing nine touchdowns against three interceptions. The return of tight end Brock Bowers gives the Raiders another weapon after he caught 10 passes for 116 yards and a touchdown in his season debut last week.
But Kansas City presents a much different challenge.
The Chiefs are also 3-0 and enter the contest averaging 416.3 yards and 29.3 points per game. Running back Kenneth Walker III leads the NFL with 360 rushing yards, giving Kansas City another offensive weapon alongside quarterback Patrick Mahomes.
The Raiders have been able to rely on takeaways and timely defensive plays to remain unbeaten. Against Kansas City, they'll have to contend with an offence capable of producing consistently and a quarterback who has plenty of experience in the AFC West.
Sunday's game will provide Las Vegas with its toughest test of the season and an opportunity to show whether its 3-0 record can withstand a division rival that is matching it at the top of the standings.
Maye looking for answers against Allen, Bills
Drake Maye was supposed to be one of the big reasons for optimism in New England this season. Instead, the Patriots quarterback has struggled badly through the first three weeks, throwing just one touchdown against six interceptions while also losing a fumble.
That makes Sunday's trip to Buffalo an especially difficult test.
The Bills are 3-0 and averaging an NFL-best 33.7 points per game, with Josh Allen once again playing at an MVP level. Allen has 11 total touchdowns through three games and has shown the ability to hurt defences with both his arm and his legs.
For Maye, the challenge is finding a way to settle down and avoid the mistakes that have plagued him early in the season. The Bills recorded seven sacks against New England in their two meetings last year, and Buffalo's pass rush has already been a problem for opposing quarterbacks this season.
The Patriots simply can't afford to give Allen and the Bills extra opportunities. New England has struggled to finish drives and protect the football, while Buffalo has been much better at turning takeaways into points.
After a 35-6 loss to Jacksonville last week, Maye gets a chance to answer some of those early-season questions against one of the toughest teams in the AFC. It is a difficult assignment, but it could also be an important opportunity for the young quarterback to get himself back on track.
Burrow, Lawrence square off
If you're looking for a potential shootout, Jaguars-Bengals could be the game.
Trevor Lawrence has never beaten Cincinnati in three career meetings, although he has put up some solid numbers.
Joe Burrow, meanwhile, is coming off a three-touchdown performance against Pittsburgh.
Since 2021, Burrow has thrown three or more touchdown passes in 28 games, the most in the NFL over that span.
There is also an intriguing matchup on the outside, with Cincinnati's Ja'Marr Chase potentially going up against Jacksonville sophomore Travis Hunter.
Both teams enter the game at 2-1, making this an important early-season showdown.
Rams, Eagles searching for answers
The Rams and Eagles both enter Week 4 with plenty to prove.
Los Angeles is 1-2 after blowing a 16-point halftime lead against Denver last week, while Philadelphia is 2-1 after losing to Chicago.
The Eagles defence has been particularly interesting.
Philadelphia has yet to record a takeaway through three games, making it the only team in the NFL without one. For a team with Super Bowl expectations, it's a concerning trend early in the season.
The Rams, meanwhile, will welcome back Puka Nacua, who missed time with an injury. That gives Matthew Stafford another weapon as he goes up against Jalen Hurts and an Eagles team trying to get back on track.
On defence, the Rams must try to move forward with some tough injuries. Already without Myles Garrett, Los Angeles lost Aaron Donald for Week 4, leaving it without the two biggest names it added to its defensive front this season.
Donald was ruled out Friday with a back injury after missing practice all week. The three-time NFL Defensive Player of the Year returned from retirement this season and played in Los Angeles' last two games, providing pressure and helping draw attention from opposing offensive lines.
Garrett, meanwhile, remains on injured reserve after undergoing knee surgery following Week 1.
Donald's absence also puts more responsibility on Kobie Turner and Braden Fiske in the middle, while Byron Young and the other edge rushers will have to help make up for Garrett's absence.
The timing is particularly difficult against Philadelphia. The Eagles have one of the league's stronger offensive lines, ranking fourth in pass-block win rate through three games, and Jalen Hurts gives Philadelphia another challenge with his ability to extend plays and make plays with his legs.
Derrick Henry returns to Tennessee
It's hard to imagine a more obvious storyline in Titans-Ravens.
Derrick Henry is going back to Tennessee.
The former Titans star will face his old team for the first time since leaving the franchise, now as a key part of Baltimore's offence.
The Titans enter the game 0-3 and are averaging just 12.3 points per game.
The Ravens, meanwhile, are 2-1 and will look to keep pace with the Cleveland Browns in the AFC North.
Game to watch: Denver Broncos (2-1) at San Francisco 49ers (3-0)
The 49ers are one of five undefeated teams entering Week 4 and have been one of the NFL's most efficient squads through the first three games. Brock Purdy leads the league with a 133.1 passer rating and has thrown nine touchdown passes without being sacked. San Francisco is also first in third-down efficiency and red-zone touchdown percentage.
Denver presents a different kind of challenge. The Broncos have won two straight after overcoming double-digit deficits against Jacksonville and the Rams, but their slow starts have been an issue. They have been outscored 40-10 in the first half this season.
The Broncos will need a better start against a San Francisco team that has been difficult to stop and has plenty of weapons around Purdy, including Christian McCaffrey, George Kittle and Deebo Samuel. Denver's defence has eight sacks through three games and will need to create pressure and force San Francisco into some difficult situations.
It is a good test for both teams: the 49ers try to remain undefeated, while the Broncos look to show they can play a complete game.
Morassutti's Favourites (Season record: 1-2)
Jaguars at Bengals — Pick: Jaguars +2.5: This has the makings of a high-scoring game, and Jacksonville has enough offensive firepower to keep this one close.
Patriots at Bills — Pick: Bills -6.5: Buffalo has been extremely difficult to stop through three weeks, while New England's offence has struggled to generate points.
Broncos at 49ers — Pick: 49ers -3.5: San Francisco is 3-0 and has been one of the league's most impressive teams early in the season. Denver has played well, but this is a difficult road test.
Full Week 4 schedule (all times ET)
Thursday, Oct. 1
Cleveland Browns 27, Pittsburgh Steelers 24
Sunday, Oct. 4
Indianapolis Colts at Washington Commanders, 9:30 a.m.
Jacksonville Jaguars at Cincinnati Bengals, 1 p.m.
Dallas Cowboys at Houston Texans, 1 p.m.
New England Patriots at Buffalo Bills, 1 p.m.
Los Angeles Rams at Philadelphia Eagles, 1 p.m.
New York Jets at Chicago Bears, 1 p.m.
Tennessee Titans at Baltimore Ravens, 1 p.m.
Green Bay Packers at Tampa Bay Buccaneers, 1 p.m.
Arizona Cardinals at New York Giants, 1 p.m.
Miami Dolphins at Minnesota Vikings, 4:05 p.m.
Denver Broncos at San Francisco 49ers, 4:25 p.m.
Los Angeles Chargers at Seattle Seahawks, 4:25 p.m.
Kansas City Chiefs at Las Vegas Raiders, 4:25 p.m.
Detroit Lions at Carolina Panthers, 8:20 p.m.
Monday, Oct. 5
Atlanta Falcons at New Orleans Saints, 8:15 p.m.
