Thatcher Demko made 29 saves and Conor Garland added an empty-netter with 1:02 left to help the Canucks (2-2-1) end a two-game slide. Vancouver connected for two goals in the second period to take the lead for good in the fifth of a six-game trip, their longest to start a season in team history.
Alex DeBrincat scored a power-play goal for sputtering Chicago, which dropped to 0-4-1. Kevin Lankinen was sharp in stopping 22 shots, but the Blackhawks again failed to cash in offensively despite outshooting the Canucks 30-25.
The Blackhawks have been outscored 21-9 this season and haven't led in any of their five games.
Dickinson opened the scoring 6:36 into the first period, ripping a one-timer from the left circle over Lankinen's glove into the upper right corner of the net. Dickinson converted Matthew Highmore's pass from behind the net.
DeBrincat's power-play goal about two minutes later tied the game. He also connected on a one-timer from the left circle that found the upper right corner _ set up by Patrick Kane with a cross-ice feed from the left side.
Pearson scored on a midair deflection of Quinn Hughes' high shot from the blue line at 9:55 of the second period to put Vancouver ahead 2-1.
Camped in front of the net and covered by Chicago's Calvin de Haan, Pearson redirected the puck downward and under Lankinen's glove as the Canucks capped a dominant shift.
Boeser made it 3-1 with 1:39 left the second, stuffing in a rebound from the left edge for the crease during a 5-on-3 power play after taking cross-ice pass from Elias Pettersson. Lankinen slid and made a right-pad save on Boeser's first attempt, but the Canucks forward followed through and popped the puck in.
It was the first power-play goal allowed this season by the Blackhawks after they had killed 10 chances against them.
The Blackhawks saluted Patrick Kane's 1,000th game in a pregame video tribute and on-ice ceremony. Kane played the milestone game back on March 9 in Dallas, but wanted to wait to celebrate it in front of a full crowd at the United Center.
Kane was joined by his family _ including his girlfriend and infant son, Patrick Kane III _ and received a silver stick from Blackhawks captain Jonathan Toews. The two stars broke into the NHL with Chicago in 2007 and anchored Stanley Cup championship teams in 2010, 2013 and 2015.
Vancouver coach Travis Green was behind the bench for this 294th regular-season game with the Canucks, tying him with Bob McCammon for fourth-most games coached in franchise history.
NOTES: Blackhawks F Dylan Strome was back in the lineup after being a healthy scratch in Chicago's first four games ? Vancouver D Hughes returned after missing Tuesday's game at Buffalo with a lower body injury? Chicago F Mike Hardman didn't play (concussion protocol) after absorbing a big hit by the Islanders' Matt Martin on Tuesday. ? Blackhawks assistant coach Tomas Mitell (COVID-19 protocol) missed the game. Player development advisor and former forward Chris Kunitz took his place on the bench.
Canucks: Conclude their six-game trip Saturday at Seattle, which will be the first home game for the Kraken.
Blackhawks: Host Detroit on Sunday.