Acquired ahead of the trade deadline last month from Columbus, Foligno has missed the Leafs' last two games with an upper-body injury suffered against the Montreal Canadiens on May 3. In four games since joining Toronto, Foligno has four assists.
Holl missed practice on Monday with an undisclosed injury. Leafs head coach Sheldon Keefe said on Tuesday that both Holl and Foligno would be game-time decisions.
Frederik Andersen will start for the Leafs in their penultimate game, his first NHL action since March 19. Puck drop is scheduled for 8 p.m. ET on Sportsnet.