Oilers coach Dave Tippett said Keith will miss the game and is day-to-day with an upper-body injury during media access before the game.
William Lagesson will replace Keith in the lineup.
Keith was forced out of Tuesday’s game against the Dallas Stars with an upper-body injury.
The team announced he would not return to the game during the second intermission. It’s unclear when or how Keith was injured.
Keith skated 10:37 against the Stars, the lowest total ice time among all Oilers defencemen after two periods.
The 38-year-old has one goal, five points and is minus-1 in 18 games this season.
The Oilers entered the Stars game already with a battered blue line, with both Darnell Nurse and Slater Koekkoek out multiple weeks with injuries.