Kassian missed three games after suffering a lower-body injury in last week's loss to the Detroit Red Wings.
The 30-year-old has three goals and five points in 10 games this season, his seventh with the team.
While it's unclear how Kassian was hurt, he told media Tuesday the injury was "a little fluke" but that he was healthy now.
"Obviously we're playing a good Winnipeg team but I'm looking forward to getting back there, playing my game and helping this team win hockey games," he said.
Kassian skated with Warren Foegele and Ryan McLeod on the third line in the morning skate. Colton Sceviour is expected to be taken out of the lineup to make room for Kassian.