He went down while making a save late in the first period and grabbed his right leg as Ryan Lomberg batted in the rebound to give the Panthers a 3-0 lead.
Demko stayed down in the crease as a trainer came out to look at him. The goalie was helped off the ice and appeared to avoid putting any weight on his right leg.
After the team’s 5-1 loss, Canucks coach Bruce Boudreau said he had no update on Demko.
Spencer Martin took over Vancouver’s crease for the final seconds of the first period and started the second. The Canucks said in a tweet that Demko would not return to the game.
It has been a difficult start to the season for Demko. He entered play with a 3-9-2 record over 14 starts with a 3.81 goals-against average and .885 save percentage.
He went 33-22-7 last season with a 2.72 GAA and .915 save percentage before missing the final three games of the campaign due to a lower-body injury.