Kane has been sidelined the past two games and is listed as day-to-day.
The Oilers face the Penguins on Thursday and then wrap up a short road trip with a game against the Columbus Blue Jackets on Saturday.
In 24 games this season, Kane has nine goals and 19 points.
Forward Klim Kostin, who has missed the past two games with an illness, did make the trip.
Watch the Oilers-Penguins game on Thursday at 7 p.m. ET / 5 p.m. MT on Sportsnet or SN NOW.