Leonard did not travel with the Raptors to the nation’s capital for their game at the Washington Wizards on Saturday night.
He had 31 points and 10 rebounds while playing 36 minutes in Toronto’s 113-101 victory over the visiting Boston Celtics on Friday.
Leonard played in only nine games for the San Antonio Spurs last season, mostly because of a quadriceps injury.
Toronto acquired him in an off-season trade that sent DeMar DeRozan to San Antonio.
The Wizards are also without their main off-season pickup, centre Dwight Howard, who is missing a second game in a row with a sore backside.
But Washington coach Scott Brooks said that point guard John Wall is ready to play, despite missing the morning shootaround because of a migraine.