Belt scored on a single by first baseman Vladimir Guerrero in the third inning when he ran home from second base. Just as the 35-year-old arrived at home plate, he reached back and grabbed his left leg.
The Blue Jays announced that he had been been removed from the game due to left hamstring tightness.
Belt was replaced by Nathan Lukes in his next at-bat, who promptly registered his first MLB-level RBI to make the score 3-0 for the Blue Jays.
Belt has been one of Toronto’s better hitters in recent weeks. He is slashing .263/.378/.434 with four homers and 16 RBI this season.