Berrios struck out five over three innings while walking one and allowing just three hits.
He started the fourth inning to face Royce Lewis, walking the Game 1 hero, but was lifted in favour of Kikuchi, a southpaw, with three of the next four hitters due up being lefties.
The Minnesota Twins had four left-handed hitters in their lineup for Game 2 of the wild-card series, so the Blue Jays will look to force the Twins to make some tough lineup decisions early in the potential series-clinching game.
In 2023, Berrios allowed a .261 average against lefties with 16 home runs. Kikuchi held hitters in the same-handed matchup to a .214 average and just six home runs.