"This was a chronic issue that Gus has been dealing with for a number of seasons," said Blue Jackets general manager Jarmo Kekalainen in a press release.
"He has been able to perform at a high level, but a cyst in the area developed over time that has inhibited his ability to continue to do so. As a result, surgery was the best course of action and we look forward to having him back at full strength this season."
Nyquist, 31, notched 42 points in 70 games during his first season in Columbus, after signing a four-year $22-million deal with the Blue Jackets in the off-season.
The native of Halmstad, Sweden has recorded 348 points in 570 career games, most of which were spent in Detroit until he was dealt by the Red Wings to the San Jose Sharks at the 2019 trade deadline.